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Iranian Journal of Toxicology، جلد ۱۰، شماره ۵، صفحات ۱۷-۲۲
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عنوان انگلیسی Helianthus annuus Leaf Ameliorates Postprandial Hyperglycaemia by Inhibiting Carbohydrate Hydrolyzing Enzymes Associated with Type-2 Diabetes
چکیده انگلیسی مقاله Background: Diabetes mellitus is a chronic disease. Decreasing postprandial hyperglycemia by retarding glucose absorption through inhibiting carbohydrates digesting enzymes (α-amylase and α-glucosidase) is one of many approaches used for the management of this disease. This study was aimed at evaluating the normoglycaemic potential of Helianthus annuus leaf. Methods: The effect of the in vitro inhibitory of different extracts (acetone, ethyl acetate and hexane) of the plant was assessed on the activities of diabetes-related enzymes (α-amylase and α-glucosidase). Results: The hexane extract of H. annuus leaf displayed the best inhibitory activity against α-amylase and α-glucosidase as indicated by the IC50 values (3.92 ± 0.02 mg mL-1) and (3.29 ± 0.12 mg mL-1), respectively. Lineweaver-Burk plot of inhibition of α-amylase and α-glucosidase by this extract showed that it was competitive and non-competitive mode, respectively. Conclusion: H. annuus leaf possesses hypoglycaemic potential which may be due to the inhibition of pancreatic α-amylase and intestinal α-glucosidase.
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نویسندگان مقاله oluwafemi adeleke ojo | oluwafemi adeleke ojo
department of biochemistry, afe babalola university, ado-ekiti, nigeria.


adebola busola ojo | adebola busola ojo
department of biochemistry, ekiti state university, ado-ekiti, nigeria.


basiru ajiboye | basiru ajiboye
department of biochemistry, afe babalola university, ado-ekiti, nigeria.


israel olayide | israel olayide
department of biochemistry, afe babalola university, ado-ekiti, nigeria.


adewale fadaka | adewale fadaka
department of biochemistry, afe babalola university, ado-ekiti, nigeria.
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-371-1&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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