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Iranian Journal of Medical Sciences، جلد ۴۱، شماره ۱، صفحات ۲-۰
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عنوان انگلیسی Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever
چکیده انگلیسی مقاله Background: Familial Mediterranean fever (FMF) has episodic or subclinical inflammation that may lead to a decrease in bone mineral density (BMD). The objective of this study was to assess BMD in Egyptian children with FMF on genetic basis. Methods: A cross sectional study included 45 FMF patients and 25 control children of both sexes in the age range between 3-16 years old. The patients were reclassified into two groups, namely group I(A) with 23 cases using colchicine for 1 month or less, and group I(B) with 22 cases using colchicine for more than 6 months. For both the patients and control groups, MEFV mutations were defined using molecular genetics technique and BMD was measured by DXA at the proximal femur and lumbar spines. Results: Four frequent gene mutations were found in the patient group E148Q (35.6%), V726A (33.3%), M680I (28.9%), and M694V (2.2%). There were also four heterozygous gene mutations in 40% of the control children. Patients receiving colchicine treatment for less than 1 month had highly significant lower values of BMD at the femur and lumbar spines than the control children (P=0.007, P< 0.001). Patients receiving colchicine treatment for more than 6 months had improved values of BMD at femur compared with the control, but there were still significant differences between them in lumbar spine (P=0.036). There were insignificant effect of gene mutation type on BMD and the risk of osteopenia among the patients. Conclusion: FMF had a significant effect on BMD. However, regular use of colchicine treatment improves this effect mainly at the femur.
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نویسندگان مقاله سمیرا صلاح | samia salah
rheumatology department, abo el-rish children hospital, cairo university, giza, egypt


سحر a el masry | sahar a el masry
biological anthropology department, medical research division, national research centre, giza, egypt


حالا فتحی sheba | hala fathy sheba
clinical pathology department, kasr el-aini hospital, cairo university, giza, egypt


rokia el محمد | rokia el banna
biological anthropology department, medical research division, national research centre, giza, egypt


walaa سعد | walaa saad
biological anthropology department, medical research division, national research centre, giza, egypt
نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/176
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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