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Iranian Journal of Medical Sciences، جلد ۲۹، شماره ۴، صفحات ۱۶۸-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Quantification of Proteinuria with Urinary Protein to Osmolality Ratios in Children
چکیده انگلیسی مقاله Background: The ratio of urine protein to urine osmolality has recently been suggested as an accurate method to determine proteinuria. Objective: We studied the correlation of urine protein to urine osmolality ratio with 24-hr urinary protein excretion. Methods: 150 children aged 0.11–17 years admitted to the Department of Pediatric Nephrology were included in this study. Early morning urine samples and 24-hr urine specimens were collected and analyzed for protein, creatinine, and osmolality. The patients with chronic renal failure were not excluded. Two groups were established: Children with no proteinuria (group 1) and those with proteinuria (group 2). Results: The optimal cutoff value of abnormal proteinuria and nephrotic range proteinuria was determined to be a protein–osmolality ratio (Up/Uosm) 0.27 and 1.59 mg/l/mOsm respectively. The correlation of 24-hr urinary protein excretion with both urinary protein/creatinine ratio (Up/Ucr) and Up/Uosm was highly significant (p< 0.001). According to the receiver operator characteristic (ROC) curves analysis, we found no differences between Up/Uosm and Up/Ucr ratios in detecting either abnormal proteinuria or nephrotic syndrome. Conclusion: Urine protein to urine osmolality ratio seems to be a simple and a valuable test for the assessment of the degree of proteinuria in children.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله n هومن | n hooman
departments of pediatric nephrology iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

h اتوکش | h otoukesh
departments of pediatric nephrology iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

h صفایی | h safaii
departments of pediatric nephrology iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

m مهرآزما | m mehrazma
departments of pathology, ali asgar children hospital, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

s یوسفی | s yousefi
departments of pathology, ali asgar children hospital, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2301
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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