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Iranian Journal of Medical Sciences، جلد ۲۹، شماره ۳، صفحات ۱۲۴-۰
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عنوان انگلیسی The Efficacy of Implant of Octacalcium Phos-phate in Combination with Bone Matrix Gelatin on Bone Regeneration in Skull Defects in Rat
چکیده انگلیسی مقاله Background: In several conditions we have face cranial bone defects. Reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons. Objective: To evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (OCP/BMG). Methods: We used 40, 5–6-week-old male Sprague-Dawley rats. A full thickness standardized trephine defect—5-mm in diameter—was made in the rat parietal bone and OCP/BMG was implanted into the defect. No OCP/BMG particles were implanted in control group that was otherwise treated identically. After sacrificing the rats chronologically and processing the tissues by routine histological procedures, 5- m m thick sections of bone were stained and examined under light microscope. Results: On the 5 th day of implantation, inflammatory cells were seen around the implanted materials, especially around the OCP particles. By the end of 21 st day, almost all of the OCP/BMG particles were absorbed and bone trabeculae, bone marrow cavities and bone marrow tissues were seen. In the control group, at the end of 21 th day, a few areas of new bone were seen near to the defect margins and host bone, however, in much less amount than in the experimental group. Conclusion: Implant of OCP/BMG appears to stimulate new bone regeneration in bone defects. These biomaterials can be used for repair of cranial bone defects.
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نویسندگان مقاله f سرگلزایی اول | f sargolzaei aval
departments of anatomy, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

سبحانی | a sobhani
departments of anatomy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

 محمد رضا عرب | m r arab
departments of anatomy, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

شیراحمد سارانی | s a sarani
departments of anatomy, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

m h حیدری | m h heydari
fasa faculty of medical sciences, fasa, iran.
نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2317
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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