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Iranian Journal of Medical Sciences، جلد ۲۹، شماره ۳، صفحات ۱۳۰-۰
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عنوان انگلیسی Effects of Betamethasone and Gentamicin on Renal Scarring Induced by Mannose-Sensitive E Coli Pyelonephritis in Rat
چکیده انگلیسی مقاله Background: Pyelonephritis can lead to renal scar. Objective : To evaluate the effects of betamethasone in preventing renal scarring in rat model of pyelonephritis. Methods : Sixty three female Sprague-Dawley rats were divided into seven groups. Group A was the control. Mannose-sensitive E coli was directly inoculated into the left kidney exposed under general anesthesia in groups C–G. Group B received normal saline. Two days after bacterial inoculation, groups C, E and F received gentamicin for 10 days. Betamethasone was injected for three days to animals in groups of D, E (2 days after bacterial inoculation) and F (5 days after bacterial inoculation). Group G received no treatment. Eight weeks after bacterial inoculation, animals were sacrificed and the volume (amount) of renal scar was determined using the stereological techniques. Results: Changes in the weight and volume of the kidneys were not statistically significant. No scar was detected in group A, but all other groups including group B with intrarenal injections showed scarring. The volume density and absolute volume of the scar in groups C–G were significantly more than group B (p< 0.001), whereas they did not differ significantly from each other. Conclusion : Betamethasone and/or gentamicin, when used two days after induction of pyelonephritis were not effective in preventing renal scar.
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نویسندگان مقاله m h فلاح زاده | m h fallahzadeh
department of pediatrics, shiraz university of medical sciences shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

a نورافشان | a noorafshan
department of anatomy, shiraz university of medical sciences shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

n تنیده | n tanideh
department of pharmacology shiraz university of medical sciences shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

h r بادلی | h r badeli
department of pediatrics, shiraz university of medical sciences shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

a بازرگانی | a bazargani
department of microbiology shiraz university of medical sciences shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2318
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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