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Iranian Journal of Medical Sciences، جلد ۲۹، شماره ۱، صفحات ۱۴-۰
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عنوان انگلیسی Effect of Endothelin-A Receptor Blockade on the Early Phase of Ischemia/Reperfusion-Induced Acute Renal Failure in Anesthetized Rats
چکیده انگلیسی مقاله Background: Previous studies have shown increases in endothelin (ET) concentration of plasma and renal tissues in acute renal failure (ARF). ET has a potent vasoconstrictor effect, through binding with its ET A receptors, and may play some roles in renal hemodynamic dysfunction in ARF. Objective: To examine the beneficial effect of a selective ET A -receptor antagonist on renal dysfunction and tissue damage occurring during the early phase of ischemia/reperfusion-induced ARF. Methods: Pentobarbital anesthetized rats were prepared for the measurement of blood pressure and renal function. A 0.5 hr clearance period was taken as control period, followed by 1 hr, and then a 4 hr experimental clearance period was taken. In ischemia/reperfusion (I/R) group, 30 min after the end of the control clearance period, renal ischemia was induced by bilateral renal artery clamping for 30 min. In drug-treated (I/R+D) group, a selective ET A -receptor antagonist (UK-350,926) was infused iv at 50 mg/kg/min for 30 min before and 2 hr following occlusion of renal arteries. There was also a sham-operated group. Results: In I/R group, renal ischemia lowered creatinine clearance (C Cr ) by 76% (p< 0.001), but elevated urine flow rate (V­ 0 ) by 2.9-fold (p< 0.01) and absolute Na + excretion (U Na V 0 ) by 3.2-fold (p< 0.05) during the 4 hr reperfusion period as compared to their own control values. In I/R+D group, V 0 and U Na V 0 did not change significantly during the 4 hr experimental period, but the amount of decrease in C Cr was equal to that of I/R group. Histological examination showed a mild degree of tissue damage in the cortex of I/R group but not in I/R+D and sham groups. Conclusion: Administration of the ET A -receptor antagonist does not prevent the fall of glomerular filtration, but it does ameliorate the damage of renal tissue and tubular reabsorption of Na­ + and water during 4 hrs of reperfusion following the ischemic challenge.
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نویسندگان مقاله s m شید موسوی | s m shid moosavi
department of physiology, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

b برمکی | b barmaki
department of physiology, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

b گرامی زاده | b geramizadeh
department of pathology, medical school, shiraz university of medi-cal sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

فلاح زاده | h fallahzadeh
department of pediatrics, nephrol-ogy section, nemazee hospital, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

e j johns | e j johns
deparment of physiology, university college cork, ireland
نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2346
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