این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Sciences، جلد ۲۷، شماره ۳، صفحات ۹۷-۰
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عنوان انگلیسی Effect of Garlic Extract on Cutaneous Leishmaniasis and the Role of Nitric Oxide
چکیده انگلیسی مقاله Background: The production of nitric oxide (NO) is important in the final outcome of leishmaniasis in animal models. Objective: The efficacy of garlic therapy and a combination of garlic and vitamin A were compared with an antimonial drug (glucantime) to assess healing and regulation of NO release in mice infected with Leishmania major . Methods: The mice were subjected to 3 ´ 10 5 promastigotes and allowed to induce a lesion. The mice were treated with above compounds twice a day for 45 days. The diameter of the lesion was measured on days 1, 10, 20, 30 and 45. In a separate experiment, NO release by peritoneal macrophages was measured. Results: The diameter of lesion was reduced by aqueous extract of garlic within 30 days of treatment. However, the maximum reduction was induced when mice were subjected to vitamin A for 10 days before the administration of the aqueous extract for 30 days. A significant correlation between healing and the amount of NO release was also found. Conclusion: A combination of aqueous extract of garlic and vitamin A can treat leishmanisis.
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نویسندگان مقاله k احمدی رنانی | k ahmadi renani


a محمودزاده | a mahmoodzadeh


am چراغعلی | am cheraghali


aa اصفهانی | aa esfahani


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2581
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