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Medical Journal of Islamic Republic of Iran، جلد ۱۹، شماره ۴، صفحات ۳۳۹-۳۴۴
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عنوان انگلیسی RELATIONSHIP OF SPERM PARAMETERS WITH LIPID PEROXIDATION IN ASTHENOZOOSPERMIC AND NORMOZOOSPERMIC MALES
چکیده انگلیسی مقاله Background: The lipid peroxides and their degradation products are highly toxic to spermatozoa and may play a major role in sperm dysfunction. The purpose of this study was to determine the level of lipid peroxidation as indicated by malondialdehyde (MDA) in the spermatozoa and seminal plasma of asthenozoospermic and normozoospermic males. In addition, correlation of lipid peroxidation with motility grades: a (rapid progressive), b (slow progressive), c (nonprogressive ), d (immotile ), percent of normal morphology, acrosome and tail defect, and concentration of spermatozoa was determined. Methods: MDA of spermatozoa and seminal plasma was determined in 35 asthenozoospermic and 15 normozoospermic men by spectrofluorometry. Semen analysis was done according to the WHO standard. Results: MDA in the spermatozoa of asthenozoospermic patients was significantly higher than normozoospermic males (0.14±0.0 1 and 0.09±0.0 1 nmol/1 0* 106 spermatozoa respectively, mean ±SE). A significant negative correlation was observed between MDA of spermatozoa with grade a motility and concentration of spermatozoa. In addition, a significant positive correlation was observed between MDA of spermatozoa with the acrosome and tail defect. The MDA value in the seminal plasma of asthenozoospermic and normozoospermic patients was 1.35±0.07 and 1.2±0.08 nmol/mL seminal plasma respectively (mean±SE). The MDA of seminal plasma exhibited a negative correlation with grade a+b motility and positive correlation with grade c+d motility and head defect. Conclusion: Lipid peroxidation has a deleterious effect on semen quality and MDA is an index of lipid peroxidation which may be a diagnostic tool for the analysis of infertility in asthenozoospermic patients.
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نویسندگان مقاله حیدر طویلانی | heidar tavilani
department of medical biochemistry, hamadan university of medical sciences, hamadan,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

محمود دوستی | mahmoud doosti
department of medical biochemistry, faculty of medicine, tehran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حجت اله سعیدی | hojatollah saeidi
, the department of medical pathology, tehran university of medical sciences, tehran,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید محمد حسینی پناه | seyed mohammad hosseinipanah
he department of anatomy, kashan university of medical sciences, kashan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

حسن حسنی بافرانی | hasan hasani baferani
he department of anatomy, kashan university of medical sciences, kashan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-23&slc_lang=en&sid=en
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