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Medical Laboratory Journal، جلد ۹، شماره ۵، صفحات ۲۸-۳۲
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عنوان انگلیسی Hemoglobin D is the Commonest Hemoglobinopathy in the North of Iran
چکیده انگلیسی مقاله Abstract Background and Objective: Normal hemoglobin (Hb) is formed of a heme group and a protein group known as globin. Globin is made of four polypeptide chains and in hemoglobinopathies, the structure of one of these four polypeptide chain becomes abnormal. Cellulose acetate method is a common way to differentiate haemoglobinopathies. Inability to identify the components of Hb low concentrations and incapability to isolate all Hb types are among the disadvantages of this method. The aim of this study was to report the prevalence of hemoglobinopathies in the North of Iran by capillary electrophoresis method. Methods: All patients with suspected hemoglobinopathies, referred by physicians for electrophoresis, have been studied in a private center in the city of Gorgan, Iran. The level of HbA2, HbA, HbF and other Hb was recorded. Results: Overall, 725 blood samples were analyzed using the capillary method. HbE was reported in 2 patients, HbH was observed in 2 patients and Hb Barts was reported in 3 patients. Using the capillary method, among patients with the SDG area, only 4 of 38 (10.52%) had HbS and the majority of them (89.48%) had HbD. Conclusion: HbD is the most common hemoglobinopathy in the North of Iran. Keywords: Hemoglobinopathy; hemoglobin D; Capillary Electrophoresis; Iran
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نویسندگان مقاله جوشقانی حمید رضا | joshaghani hamid reza
laboratory science research center, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

پرویزی سعید | parvizi saeid
golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

کلوی خدابردی | kalavi khodaberdi
laboratory science research center, golestan university of medical sciences, gorgan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

بهنام پور ناصر | behnampour naser
hematology and oncology research center, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

جوشقانی هادی | joshaghani hadi
shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نادر هاشمی | nader hashemi
department of medical biotechnology laboratory science research center, golestan university of medical science, gorgan, iran

سازمان اصلی تایید شده: دانشگاه گلستان (Golestan university)

نشانی اینترنتی http://www.goums.ac.ir/mljgoums/browse.php?a_code=A-10-1-371&slc_lang=fa&sid=fa
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