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Medical Journal of Islamic Republic of Iran، جلد ۱۹، شماره ۲، صفحات ۱۵۹-۱۶۴
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عنوان انگلیسی LONG TERM ORAL ETOPOSIDE AS SECOND-LINE THERAPY IN RECURRENT EPITHELIAL CARCINOMA OF THE OVARY
چکیده انگلیسی مقاله Background: The activity and toxicity of etoposide in women with recurrent ovarian cancer was evaluated in a case series of women with recurrent ovarian cancer who had measurable disease, Methods: All patients had plior platinum-based chemotherapy and developed progressive disease, Etoposide was given as 50mg/day for 21 days every 4 weeks until progression of disease or prohibitive toxicity, Between December 1999 and January 2004,32 patients were enrolled in this study. Results: 30 patients received a total of 133 cycles of etoposide. Median age was 49 years (range, 19 to 75). The median number of etoposide cycles was 4 (range, 1 to 12). There were 5 partial responses (16.6%). The mean response duration was 4.8 months (range, 3.5 to 6). median progression-free interval CPFI) was 7 months (range, 3 to 13), and median survival time was 12.5 months (range. 1.3 to 36). Conclusion: The major toxicity was leukopenia. One patient required red blood cell transfusions, and the main non-hematologic toxicity was nausea and vomiting. There were no treatment-related mortalities. Although etoposide appears to exhibit modest activity in recurrent ovarian cancer after platinum-based therapy, response and survival durations are short.
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نویسندگان مقاله اعظم سادات موسوی | azam sadat moosavi
from the department of gynecology oncology, vali asr hospital, vali asr reproductive research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

افسانه تهرانیان | afsaneh tehranian
from the department of gynecology oncology, vali asr hospital, vali asr reproductive research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نادره بهتاش | nadereh behtash
from the department of gynecology oncology, vali asr hospital, vali asr reproductive research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

میترا مدرس گیلانی | mitra modares gilani
from the department of gynecology oncology, vali asr hospital, vali asr reproductive research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاطمه قایم مقامی | fatemeh ghaem maghami
from the department of gynecology oncology, vali asr hospital, vali asr reproductive research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-798&slc_lang=en&sid=en
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