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Medical Journal of Islamic Republic of Iran، جلد ۱۹، شماره ۱، صفحات ۷-۱۲
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عنوان انگلیسی A MULTICENTER STUDY TO EVALUATE THE SAFETY AND EFFICACY OF HEBER ON (INTERFERON ALFA-2b) IN COMBINATION WITH RIBAVIRIN FOR THE TREATMENT OF CHRONIC HEPATITIS C IN IRAN
چکیده انگلیسی مقاله  ABSTRACT Background: Combination therapy with interferon and ribavirin is the most effective treatment for chronic hepatitis C today. The aim of this study was to evaluate the efficacy and safety of thrice-weekly Heberon (interferon alfa-2b) in combination with ribavirin as first -line treatment of chronic hepatitis C. Methods: A total of97 treatment-naive patients received Heberon three million units thrice-weekly subcutaneously in combination with ribavirin for 12 months. Serum HCV RNA levels were measured before and during therapy and 6 months after the end of therapy. End-of-treatment and sustained virological responses was defmed as an undetectable HCV-RNA level at the end of treatment, and 6 months after treatment was completed (end of follow-up), respectively. Results: In an intent-to-treat analysis, HCV-RNA was undetectable at the end of treatment in 49.5% of patients. At the end of follow-up, sustained virological response was 36.1 %. Combination treatment was generally well tolerated. Six patients stopped therapy because of side effects: severe cytopenia (n=4), depression (n=1), and hyperthyroidism (n= 1 ). Common side effects of therapy include: Flu-like syndrome (85.6%), generalized alopecia (41.2% ), injection site inflammation (37.1% ), mood changes (36% ), anorexia (34%) and weight loss (32% ). Conclusion: Heberon as an IFN product in combination with ribavirin for treat-ment of patients with chronic hepatitis Cis relatively safe, feasible, and potentially efficacious. It has comparable results in achieving end-of-treatment and sustained virological responses in chronic hepatitis C.
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نویسندگان مقاله h فروتن | h. forootan
digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a شریفی | a. sharifi
digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

sh دکتر شهرام میرمومن | sh. mirmomen
digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

n دریانی | n. daryani
digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

h غفرانی | h. ghofrani
digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m فره وش | m. farahvash
digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m نصیری | m. nasiri
digestive research centel; tehran university of medical sciences, imam khomeini hospital, tehran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m طالبی | m. talebi
department of gastroenterology and hepatology, esfahan university of medical sciences,alzahra hospital, esfahan

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

a قویدل | a. ghavidel
department of gastroenterology and hepatology, tabriz university of medical sciences, imam khomeini hospital, tabriz.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

h وثوقی نیا | h. vosoghinia
department of internal medicine, mashhad,university of medical sciences, ghaem hospital, mashuniversity of medical sciences, ghaem hospital, university of medical sciences, ghaem hospital, mashhad.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

f منصورقناعی | f. mansourghanaei
university of medical sciences, razi hospital, rasht.


m زاهدی | m. zahedi
samenolhojaj therapeutic center, kerman.


h دکتر شهرام میرمومن | h. mirmomen
department of internal medicine, ahvaz university of medical sciences, sina hospital, ahvaz.


m عزمی | m. azmi
department of internal medicine, ahvaz university of medical sciences, sina hospital, ahvaz.


m امیریان | m. amirian
department of internal medicine, zahedan university of medical sciences, emam khomeini hospital,zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-253&slc_lang=en&sid=en
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