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Medical Journal of Islamic Republic of Iran، جلد ۱۹، شماره ۱، صفحات ۱-۵
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عنوان انگلیسی RECOMBINANT ERYTHROPOIETIN AND BLOOD TRANSFUSION IN VERY LOW BIRTH WEIGHT INFANTS
چکیده انگلیسی مقاله  ABSTRACT Background: Very low birth weight infants ( < 1500 g) frequently require blood transfusions because of repeated blood sampling accompanied by anemia of prematurity. Methods: In an attempt to identify the effect of human recombinant erythropoietin to decrease the requirement for blood transfusions, erythropoietin was administered to 24 pre term infants less than 1500 g prospectively from September 1999 till December2000. Data about the characteristics of the population, the severity of diseases, and treatment with erythropoietin, clinical diagnosis, initial and subsequent hemoglobin, volume of blood loss, and the number of blood transfusions were recorded. These results were compared with data from the recorded information of 49 infants who did not receive erythropoietin during those past 2 years. There were no differences between the 2 groups with regard to the gestational age, birth weight, clinical diagnosis, severity of the illness, primary causes of admission, and initial hematologic parameters such as hemoglobin, hematocrit and reticulocytes. Erythropoietin was administered in a dose of 200 ill/kg three times weekly for 6-8 weeks accompanied with iron supplement 6 mg/ kg/day. Transfusions were administered according to protocol. Results: There was no significant difference between the number of blood transfusion among these 2 groups (p= 0.07). However, transfusions in the erythropoietin treated group were fewer in comparison to the other group (1.9 +1-1.6 to 3.2 +/-1.1). No difference was observed between final hemoglobin and hematocrit levels among the two groups (10.3 +1- 0.9 vs. 10.4 +1- 0.7 and 33.7 +1- 2.3 vs. 32.2 +1- 2.2). Conclusion: Very low birth weight infants receive frequent blood transfusions but a reduction in transfusion requirements was not apparent after administration of erythropoietin and iron in preterm infants in this study. However, the lack of impact on transfusion requirements fails to support routine use of erythropoietin.
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نویسندگان مقاله ملیحه کدیور | maliheh kadivar
1department of pediatrics, children s medical center; tehran university of medical sciences,tehran- iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

هادی سمایی | hadi samaei
department of pediatrics, alias ghar children s hospital, iran university of medical sciences, tehran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

حبیبه مظفری | habibeh mozaffari
immunology, asthma and allergy research institute, children s medical center; tehran university of medical sciences, tehran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کرامت نوری | keramat nouri
department of statistics, faculty of health amp; biostatistics, tehran university of medical sciences.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مجتبی مجتهدزاده | modjtaba modjtahedzadeh
department of clinical pharmacology, faculty of pharmacology, tehran university ofmedical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-252&slc_lang=en&sid=en
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