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Medical Journal of Islamic Republic of Iran، جلد ۱۸، شماره ۴، صفحات ۳۶۵-۳۷۰
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عنوان انگلیسی INDUCTION OF TYPE 1 DIABETES IN DIABETES-RESISTA NT (BB-DR) RATS
چکیده انگلیسی مقاله The BioBreeding- Diabetes Prone (BB-DP) rat spontaneously develops an autoimmune diabetic syndrome that is dependent on the RT1 u Major Histocompatibility Complex (MHC) haplotype and homozygosity for an allele at the Lymphopenia (Lyp) locus. Lyp mutation is responsible for a peripheral T -lymphopenia. There are other genetic loci contributing to diabetes susceptibility in this strain. BB rats carrying wildtype Lyp alleles are not lymphopenic and are resistant to spontaneous diabetes (Diabetes R esistant [DR]). Our study shows that thymectomy and exposure to one sublethal dose of g-irradiation (TX-R) at 4 weeks of age result in the rapid development of insulitis followed by diabetes in 100% of DR rats. Administration of CD45RCCD4+ TCRcb+ T cells from unmanipulated syngeneic donors immediately after irradiation prevents the disease. Splenic T cells from TX -R induced diabetic animals adoptively transfer type 1 diabetes to T-deficient recipients. WAG, WF and LEW strains are resistant to TX -R induced insulitis/ diabetes. This novel model of TX -R induced diabetes in BB-DR rats can be used to identify environmental and cellular factors that are responsible for the initiation of antipancreatic autoimmunity.
کلیدواژه‌های انگلیسی مقاله BB-DR, type 1 diabetes, TX-R, BB-DP.
نویسندگان مقاله لیلی یزدچی مرندی | leili yazdchi marandi
from the immunology department, faculty of medicine, tabriz university of medical sciences, tabriz, iran,and the departments of immunology and medicine, sunnybrook and women s college health sciences center, university of toronto, toronto, ontario, canada

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

sheela ramanathan | sheela ramanathan
the departments of immunology and medicine, sunnybrook and women s college health sciences center, university of toronto, toronto, ontario, canada


philippe poussier | philippe poussier
the departments of immunology and medicine, sunnybrook and women s college health sciences center, university of toronto, toronto, ontario, canada
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-80&slc_lang=en&sid=en
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