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Medical Journal of Islamic Republic of Iran، جلد ۱۸، شماره ۴، صفحات ۳۰۳-۳۰۷
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عنوان انگلیسی USE OF MYELOPEROXIDASE INDEX AS A SUITABLE TOOL TO MONITOR RESPONSE TO THERAPY IN PATIENTS WITH MEGALOBLASTIC ANEMIA
چکیده انگلیسی مقاله Repeated bone marrow examination was found to be of value in assessing response to treatment in megaloblastic anemia. The objective of this study was monitoring the response of megaloblastics to treatment, concerning the location of neutrophilic myeloperoxidase and myeloperoxidase index (MPXI) and their variation in megaloblastic erythroid progeny. It is possible to follow up megaloblastic cases using a Technicon HI (Bayer) automated cell counter. Complete blood counts (CBC) of 50 patients whose bone marrow aspirations revealed megaloblastic state and subsequently responded to treatment with B 12 and folate were studied through pre- and post-treatment measurements. MPXI level in 41 patients was above normal range (normal: -10 to + 10). Nine patients had normal MPXI, though mean cell volume (MCV) was higher than 100 fL. The highest value of MPXI was 41.5 .The mean values of MPXI were 18.3 and 2.05 in pre- and post-treatment measurements respectively. MPXIs were decreased after treatment in 92% of patients (p= 0.008). According to this investigation, the MPXI measurement is a suitable test in monitoring the response for treatment.
کلیدواژه‌های انگلیسی مقاله Myeloperoxidase index, treatment, megaloblastic
نویسندگان مقاله j عیوضی ضیایی | j eivazi ziaei
from shahid ghazi hematology oncology research department, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

i اسودی کرمانی | i asvadi kermani
shahid ghazi hematology oncology research department, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-70&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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