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Dental Research Journal، جلد ۱۲، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی Biodegradable nanocomposite coatings accelerate bone healing:In vivo evaluation
چکیده انگلیسی مقاله poly (lactide-co-glycolide)/bioactive glass/hydroxyapatite (PBGHA) and poly (lactide-co-glycolide)/ bioactive glass (PBG) nanocomposite coatings with bone. Materials and Methods: Sol-gel derived 58S bioactive glass nanoparticles, 50/50 wt% poly (lactic acid)/poly (glycolic acid) and hydroxyapatite nanoparticles were used to prepare the coatings. The nanocomposite coatings were characterized by scanning electron microscopy, X-ray diffraction and atomic force microscopy. Mechanical stability of the prepared nanocomposite coatings was studied during intramedullary implantation of coated Kirschner wires (K-wires) into rabbit tibia. Titanium mini-screws coated with nanocomposite coatings and without coating were implanted intramedullary in rabbit tibia. Bone tissue interaction with the prepared nanocomposite coatings was evaluated 30 and 60 days after surgery. The non-parametric paired Friedman and Kruskal-Wallis tests were used to compare the samples. For all tests, the level of signifi cance was P < 0.05. Results: The results showed that nanocomposite coatings remained stable on the K-wires with a minimum of 96% of the original coating mass. Tissue around the coated implants showed no adverse reactions to the coatings. Woven and trabecular bone formation were observed around the coated samples with a minimum infl ammatory reaction. PBG nanocomposite coating induced more rapid bone healing than PBGHA nanocomposite coating and titanium without coating ( P < 0.05). Conclusion: It was concluded that PBG nanocomposite coating provides an ideal surface for bone formation and it could be used as a candidate for coating dental and orthopedic implants. Key Words: Bioactive, biocompatibility, biodegradable, nanocomposite coating, surgery
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نویسندگان مقاله مهدی مهدیخانی نهرخلجی | mehdi mehdikhani nahrkhalaji


محمد حسین فتحی | mohammad hossein fathi


وجیهه السادات مرتضوی | vajihesadat mortazavi


سید بهروز موسوی | sayed behrouz mousavi


علی اخوان | ali akhavan


عباس حقیقت | abbas haghighat


بتول هاشمی بنی | batool hashemi beni


سید محمد رضوی | sayed mohammad razavi


فاطمه مشهدی عباس | fatemeh mashhadiabbas


نشانی اینترنتی http://drj.mui.ac.ir/index.php/drj/article/view/1669
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زبان مقاله منتشر شده en
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