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Dental Research Journal، جلد ۱۰، شماره ۵، صفحات ۰-۰
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عنوان انگلیسی In vivo biocompatibility of Resilon compared with gutta-percha in a pre-clinical model
چکیده انگلیسی مقاله Background: The aim of this study was to investigate in vivo biocompatibility of Resilon, compared with gutta-percha, at short and long-term following implantation in a rat subcutaneous implantation model. Materials and Methods: Male Wistar rats were implanted subcutaneously with either Resilon or gutta-percha or were sham controls. Tissues were harvested at 8 days or 60 days after implantation and were evaluated histologically for inflammation and fibrous encapsulation. The severity of histologic injury, scored on a scale of 0-4 and quantitative analysis of the capsule wall thickness were determined for statistical analysis. Data were analyzed by Student t -test, one-way analysis of variance, Kruskal-Wallis or Mann-Whitney’s tests as appropriate. A value of P ≤ 0.05 was considered statistically significant. Results: No behavioral changes or visible signs of physical impairment were observed at 8 days or 60 days post-implantation. Histopathologic observation of the implanted sites at each timepoint showed that both Resilon and gutta-percha implants induced foreign body reaction, showing minimal to mild inflammatory reactions in most cases, which diminished significantly with time. Compared with gutta-percha, the capsule wall was thinner ( P > 0.05) after Resilon implantation at day 8 and significantly ( P = 0.01) thicker at day 60. In addition, capsule wall thickness showed a trend to increase with time after implantation in the Resilon groups ( P > 0.05), opposed to the significant decrease ( P = 0.016) observed after implantation in the gutta-percha groups, suggesting lesser long-term biocompatibility of Resilon. Conclusion: Our findings validate Resilon as an in vivo biocompatible material. However, our data suggest that long-term biocompatibility of Resilon, despite validated, is inferior to that of guttapercha control. Key Words: Endodontic materials, gutta-percha, rat, Resilon, subcutaneous implantation
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نویسندگان مقاله میگویل cardoso | miguel cardoso


رودریگو f مارکوس | rodrigo f marques


ماریا francelina lopes | maria francelina lopes


antónio s cabrita | antónio s cabrita


joão میگویل سانتوز | joão miguel santos


نشانی اینترنتی http://drj.mui.ac.ir/index.php/drj/article/view/1504
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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