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Medical Journal of Islamic Republic of Iran، جلد ۱۸، شماره ۲، صفحات ۱۴۷-۱۵۲
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عنوان انگلیسی TELOMERASEACTIVITYIN IRANIAN PATIENTS WITH ESOPHAGEAL SQUAMOUS CELL CARCINOMA
چکیده انگلیسی مقاله Telomerase activation is one of the main pathways to immortalize cancer cells. In many kinds of cancer cells, this special reverse transcriptase stabilizes and elongates telomeres and prevents telomere erosion that naturally occurs in every cell division. Esophageal cancer is the fifth most frequent cause of cancer death worldwide, and is highly associated with alcohol, smoking, cultural habits, and environmental factors. Telomerase has been suggested as a tumor marker and a molecular target for drug design in several kinds of cancers. In this work telomerase activation was inspected among Iranian patients with Esophageal Squamous Cell Carcinoma (ESCC), and detected in 90% of samples of different stages. This may be an indication that telomerase activation happens in an initial step in the development of ESCC. Although there is no correlation between telomerase activity and the progress of ESCC, it could be considered as a good tumor marker in ESCC. Telomerase activity tests are suggested for screening purposes in high risk areas for ESCC, which can be easily done on a small amount of scrapped samples of esophageal mucosa. It is also possible that ESCC results from incomplete differentiation or a failure in telomerase gene switching off that nonnally occurs during the differentiation of esophageal epithelial cells.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله s کاظمی نورعینی | s kazemi noureini
from the institute of biochemistry and biophysics. p 0. box 13145-1384. university of tehran. tehran.

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

aa ضیایی | aa ziaee
from the institute of biochemistry and biophysics. p 0. box 13145-1384. university of tehran. tehran.

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

f رستگار jazli | f rastegar jazli
national research center for genetic engineering and biotechnology nrcgeb . tehran

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

my azdanbod | my azdanbod
department of surgery. shariati hospital. tehran university o medical sciences. tehran. iran.

سازمان اصلی تایید شده: موسسه تحقیقات بیوتکنولوژی

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-94&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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