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Medical Journal of Islamic Republic of Iran، جلد ۱۸، شماره ۲، صفحات ۹۵-۹۹
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عنوان انگلیسی THE MUTATIONS OF RET PROTO-ONCOGENE IN MEDULLARY THYROID CARCINOMAS IN IRAN
چکیده انگلیسی مقاله MeduIIary thyroid carcinoma (MTC) occurs both sporadically and in the autosomal dominantly inherited multiple endocrine neoplasia (MEN) type 2 syndromes. The distinction between true sporadic MTC and a new mutation familial case is important for future clinical management of both the patient and family. The susceptibility gene for hereditary MTC is the RET proto-oncogene. DNA analysis for germline mutations of the RET proto-oncogene was performed in a series of 24 patients with MTC [apparently sporadic MTC (20 cases), familial MTC (2 cases), MEN 2A (one case) and MEN 2B (one case)] to determine whether they were true sporadic cases or hereditary forms. Genomic DNA was amplified using polymerase chain reaction (PCR) and oligonucleotide primers for exons 10 & I 1. The PCR products were examined by restriction enzymes analysis to detect the mutations. One of the 20 patients with apparent sporadic MTC had exon 10 mutation (Cys-620 Arg) and exon I I mutation (Cys- 634 Trp) was also found in the index case with MEN 2A. No mutation was detected in the other patients. Three of six evaluated members of the MEN 2A patient had the same mutation. We conclude that routine application of RET proto-oncogene testing should be included in all cases of apparent sporadic MTC.
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نویسندگان مقاله ایرج نبی پور | iraj nabipour
from the endocrine research center; shaheed beheshti university of medical sciences, tehran, the persian gulf health research center; bushehr university of medical sciences, bushehr and the endocrine research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

فاطمه حاجی قاسمی | fatemeh haji ghasemi
from the endocrine research centel; shaheed beheshti university of medical sciences, tehran, the persian gulf health res

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

شهریار کیایی | shahriar kiai
from the endocrine research centel; shaheed beheshti university of medical sciences, tehran, the persian gulf health res

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

رضا دکتر رضا برادر جلیلی | reza baradar jalili
from the endocrine research centel; shaheed beheshti university of medical sciences, tehran, the persian gulf health res

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

فریدون عزیزی | fereidoun azizi
from the endocrine research centel; shaheed beheshti university of medical sciences, tehran, the persian gulf health res

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-83&slc_lang=en&sid=en
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