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Medical Journal of Islamic Republic of Iran، جلد ۱۸، شماره ۱، صفحات ۳۵-۳۸
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عنوان انگلیسی ROLE OF MAGNESIUM LOADING TEST IN DETECTING HYPOMAGNESEMIA IN CRITICALLY ILL PATIENTS
چکیده انگلیسی مقاله Magnesium (Mg) deficiency has not usually been considered in clinical practice due to lack of relevant blood tests and because the symptoms are often vague and nonspecific. Serum concentrations may not adequately reflect Mg status. Mg Loading Test (MLT) can provide infonnation on total body Mg stores. We prospectively studied 21 critically ill patients (10 male, 11 female) admitted to the ICU, to investigate the prevalence of Mg deficiency. Their mean age was 50±21 years. To determine serum Mg, venous blood specimens were obtained just before the MLT. Mg sulfate (30 mmol) was infused during an 8-hr period and 24-hr urine samples were collected from the starting of Mg infusion. Although low serum Mg « 1.8 mmol/L) was present only in 2 patients, MLT showed Mg deficiency in 18 patients. MLT detected Mg deficiency in 13 out of 14 patients with normal serum Mg, in 2 out of 2 subjects with hypomagnesemia, and in 3 out of 5 cases with hypennagnesemia. 0f7 fetal cases, 6 occurred in individuals with hypomagnesemia (6118) and 1 death occurred in the nonnomagnesemic group (1/3). There was no relationship between Mg retention, age (r= 0.33,p= 0.63) and serum Mg concentrations (r= 0.15,p= 0.925). There was a significant correlation between Mg uptake and APACHE II score (r= 0.46,p= 0.035). In conclusion, Mg depletion is highly prevalent in ICU patients according to MLT. MLT is superior to serum Mg in determining actual Mg status in this group. Therefore, we suggest that MLT, and not serum Mg, should be carried out in patients when Mg deficiency is suspected.
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نویسندگان مقاله sm سهروردی | sm sohrevardi
the faculty of pharmacy, kerman university of medical sciences, kerman, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

m مجتهدزاده | m mojtahedzadeh
intensive care unit, sina medical center; tehran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

s صدرای | s sadray
the faculty of pharmacy, tehran university of medical sciences, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a نجفی | a najafi
intensive care unit, sina medical center; tehran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

jd اسپنس | jd spence
the stroke prevention and atherosclerosis research centre, lhsc, canada.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

c munoz | c munoz
the stroke prevention and atherosclerosis research centre, lhsc, canada.

سازمان اصلی تایید شده: 0 دانشگاه های خارج از کشور

h توکلی | h tavakoli
intensive care unit, sina medical center; tehran university of medical sciences

سازمان اصلی تایید شده: 0 دانشگاه های خارج از کشور

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-108&slc_lang=en&sid=en
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