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Medical Journal of Islamic Republic of Iran، جلد ۱۷، شماره ۱، صفحات ۱۵-۱۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی LAMOTRIGINE AS ADD-ON THERAPY IN CHILDREN WITH DRUG-RESISTANT EPILEPSY (IRANIAN EXPERIENCE)
چکیده انگلیسی مقاله Lamotrigine (LTG), a newly developed antiepileptic drug (AED), is efficacious in treating refractory epilepsy. This study was designed to evaluate the efficacy and safety of LTG as add-on therapy in 40 children with refractory epilepsy. The trial was an open-labeled prospective study in children with drug-resistant epilepsy aged < 14 years, who had at least 4 seizures per month in spite of receiving at least 3 AED's. Initial LTG dose and titration was adjusted based upon the AED's which were taken simultaneously. Lamotrigine was increased in steps to maximal dose within 4 weeks and maintained for 3 months while pre-existing AED's remained unchanged. Overall efficacy was defined if >50% reduction of seizure frequency was achieved during 3 months follow up. Hematological and biochemical parameters were checked before and after the trial in all patients. The evaluation of drug safety consisted of chart review for treatment-emergent adverse events. Among 40 patients who completed the trial, 21 of them (52.5%) had >50% reduction in seizure frequency. Lamotrigine was effective in all seizure types, particularly typical absence. Lennox-Gastaut syndrome also responded well. Skin rashes occured in 5 patients (10.6%) and resulted in LTG discontinuation. No significant changes were noted in laboratory results. These results indicated that LTG is well tolerated and is effective in controlling a variety of seizure types, especially absence epilepsy
کلیدواژه‌های انگلیسی مقاله Lamotrigine, refractory epilepsy, add-on therapy.
نویسندگان مقاله m برزگر | m barzegar
thedept. of pediatric neurology, tabriz children hospital, tabriz university of medical sciences, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

sh تنکابنی | sh tonekaboni
from the department of pediatrics neurology, mofid children hospital, shahid beheshti university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

m غفرانی | m ghofrani
from the department of pediatrics neurology, mofid children hospital, shahid beheshti university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-171&slc_lang=en&sid=en
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