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Medical Journal of Islamic Republic of Iran، جلد ۱۶، شماره ۳، صفحات ۱۷۹-۱۸۲
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عنوان انگلیسی A STUDY ON THE APPLICATION AND EFFICACY OF SOLVENT-DETERGENT (SID) TREATMENT IN THE PROCESS OF PURIFYING FACTOR VII FROM PROTHROMBIN COMPLEX
چکیده انگلیسی مقاله The risks of transmitting viral infection by blood and plasma-derived products have long been known and still remain an area of concern. In this study, in the process of purifying human factor VII from prothrombin complex, SID treatment using tri-n-butyl phosphate and Tween 80 was employed and its capability and efficacy was studied. The results indicated that the process did not affect the biological function of the essential coagulation factors studied. In addition, the process was shown to be effective on enveloped viruses, where its inactivation factor for the model used, Herpes Simplex type I, was 5.5 logs. However, the procedure was not effective on poliovirus which was used as a model for non-enveloped viruses. It is therefore concluded that for increasing viral safety it is best to apply at least one more inactivating procedure which will be effective on non-enveloped viruses as well.
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نویسندگان مقاله h رضوان | h rezvan
from the research and development department, blood research and fractionation co., tehran


s نصیری | s nasiri
from the research and development department, blood research and fractionation co., tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

k موسوی | k mousavi
from the research and development department, blood research and fractionation co., tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

m گلابی | m golabi
virology dept., iran university of medical sciences, tehran, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-208&slc_lang=en&sid=en
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