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Medical Journal of Islamic Republic of Iran، جلد ۱۶، شماره ۳، صفحات ۱۶۹-۱۷۲
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عنوان انگلیسی A SURVEY OF CELLULAR IMMUNITY, TOTAL T-LYMPHOCYTE, T-ACTIVE , B-LYMPHOCYTE A ND T-CELL FUNCTION IN RELATION TO PHYTOHEMAGGLUTININ (PHA) IN THALASSEMIC PATIENTS
چکیده انگلیسی مقاله The aim of this study was to evaluate the immune system and lymphocyte function in 41 Iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. The patients consisted of 20 splenectomized and 21 non-splenectomized patients. They were treated with Desferal, and had received repeated blood transfusion. Laboratory investigations included measurement of total T lymphocytes, active T lymphocytes, B-Iymphocytes and function of lymphocytes treated with PHA. In this study we observed a significant reduction of active T lymphocytes and total T lymphocytes in the patient group compared to controls (p< 0.005 & p< 0.001), but there was no significant difference between splenectomized and non-splenectomized patients. Also in both groups, lymphocyte function was reduced against PHA (phytohemagglutinin) compared with the controls, and the numbers of B cells were increased. These results lead to the conclusion that the deficient immune system in β-thalassemia causes infectious diseases, which finally leads to death. Therefore, stimulation of the immune system as well as clinical treatment may prevent infectious disease in patients with β- thalassemia.
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نویسندگان مقاله t زندیه | t zandieh
from the iranian blood transfusion service, tehran, and the department of hematology, pediatric medical center, tehran


f طرآبادی | f tarabadi
from the iranian blood transfusion service, tehran, and the department of hematology, pediatric medical center, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a tabatabaiyan | a tabatabaiyan
from the iranian blood transfusion service, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m ایزدیار | m izadyar
the department of hematology, pediatric medical center, tehran university of medical sciences, tehran, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-205&slc_lang=en&sid=en
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