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Medical Journal of Islamic Republic of Iran، جلد ۱۶، شماره ۳، صفحات ۱۲۳-۱۲۸
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عنوان انگلیسی A 20-YEAR SURVEY OF INFECTIOUS COMPLICATIONS IN 64 PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
چکیده انگلیسی مقاله Common variable immunodeficiency (CV ID) is a heterogeneous primary immunodeficiency disorder, characterized by hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. To determine the spectrum of infectious complications in patients with common variable immunodeficiency (CV ID), we reviewed the hospital records of 64 CVID patients, who were diagnosed in Children's Medical Center during a period of 20 years. Among our patients, there were 38 males and 26 females, with a median age of 12 years (2-42 years) at the time of study. The median age of diagnosis was 6.1 years, with an average diagnostic delay of 5.2 years in our patient's group. Almost all of our patients have suffered from acute and recurrent infections, particularly in the respiratory and gastrointestinal systems. The majority of patients (82.5%) had pneumonia prior to diagnosis. The other infectious complications seen in our patients were as follows: recurrent otitis media (54%), recurrent sinusitis (50.8%), diarrhea (65.1 %), and bacterial meningitis (11.1 %). Unusual or opportunistic infections were also seen in some of our patient population, including oral candidiasis in 10 patients, and Pneumocystis carinii pneumonia in 2 subjects. Based on this study, we suggest that hypogammaglobulinemia should be considered in any patient with a history of recurrent infections in different organs, and such patients should have a full assessment of the immune system.
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نویسندگان مقاله a آقامحمدی | a aghamohammadi
from the department if clinical immunology, allergy and asthma, children s medical center, tehran university of medical sciences, tehran. i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a فرهودی | a farhoudi
from the department if clinical i mmunology, allergy and asthma, children s medical center, tehran university of medica

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m معین | m moein
from the department if clinical i mmunology, allergy and asthma, children s medical center, tehran university of medica

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

z پورپاک | z pourpak
from the department if clinical i mmunology, allergy and asthma, children s medical center, tehran university of medica

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

n رضایی | n rezaei
from the department if clinical i mmunology, allergy and asthma, children s medical center, tehran university of medica

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

k ابوالمعالی | k abolmaali
from the department if clinical i mmunology, allergy and asthma, children s medical center, tehran university of medica

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m موحدی | m movahedi
from the department if clinical i mmunology, allergy and asthma, children s medical center, tehran university of medica

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m قره گوزلو | m gharagozlou
from the department if clinical i mmunology, allergy and asthma, children s medical center, tehran university of medica

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

b میرسعید قاضی | b mirsaeidghazi
from the department if clinical i mmunology, allergy and asthma, children s medical center, tehran university of medica

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m محمودی | m mahmoudi
from the department if clinical i mmunology, allergy and asthma, children s medical center, tehran university of medica

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-198&slc_lang=en&sid=en
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